Key result
Pentraxin 3 (PTX3) participates in regulating insulin secretion, glucose metabolism, and ovarian function, playing a role in the pathogenesis of polycystic ovary syndrome and its complications.
Why the study?
To review the mechanism of pentraxin 3 in polycystic ovary syndrome and its complications to provide new directions for pathogenesis, diagnosis, and treatment.
Pentraxin 3 plays a multifaceted role in the pathogenesis of polycystic ovary syndrome and its complications, including cardiovascular diseases, offering potential new directions for diagnosis and treatment.
Polycystic ovary syndrome (PCOS) is a common endocrine disease of child-bearing period women and one of the main causes of infertility in women. Pentraxin 3 (PTX3) is a multifunctional protein with a series of biological activities. PTX3 participates in the regulation of insulin secretion and glucose metabolism, ovarian cumulus cell function, inflammatory factor activity, androgen metabolism, lipid absorption and transport, and endothelial cell function, thereby improving insulin resistance, promoting follicular development and ovulation, reducing chronic inflammation, inhibiting androgen levels, improving lipid metabolism abnormalities and preventing atherosclerosis and cardiovascular diseases, thus participating in the occurrence of PCOS and its complications. This article reviews the mechanism of PTX3 in PCOS and its complications, trying to provide new ideas and directions for the study of PCOS pathogenesis and its clinical diagnosis and treatment.
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Wu et al. (2020) conducted a review in Polycystic ovary syndrome (PCOS). Pentraxin 3 (PTX3) was evaluated. Pentraxin 3 (PTX3) participates in regulating insulin secretion, glucose metabolism, and ovarian function, playing a role in the pathogenesis of polycystic ovary syndrome and its complications.
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