Key result
Alkalinization induces SR Ca2+ release via ruthenium red-sensitive channels and increased ruthenium red-insensitive efflux.
Why the study?
Does alkaline pH affect sarcoplasmic reticulum Ca2+ release and uptake in isolated frog or rabbit sarcoplasmic reticulum vesicles?
Population
Isolated frog or rabbit sarcoplasmic reticulum vesicles
Design
Preclinical
Authors
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Alkalinization effects on SR Ca2+ release should not yet change clinical pH targets; leaves open translation to intact cardiac or skeletal muscle in vivo.
Does alkaline pH affect sarcoplasmic reticulum Ca2+ release and uptake in isolated frog or rabbit sarcoplasmic reticulum vesicles?
Alkaline pH induces Ca2+ release from the sarcoplasmic reticulum via two distinct pathways, which may be physiologically significant during excitation-contraction coupling.
Dettbarn et al. (1991) studied this question. Alkaline pH was evaluated on Ca2+ release and Ca2+ uptake. Alkalinization induces Ca2+ release from sarcoplasmic reticulum vesicles via direct activation of ruthenium red-sensitive channels and increased ruthenium red-insensitive Ca2+ efflux.
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