Population
Sarcoplasmic reticulum vesicles (intact and leaky)
Comparison
Addition of MgATP (and CaATP in absence of MgCl2) vs Intact vs leaky vesicles; MgATP vs CaATP
Design
Preclinical
Authors
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Supports SERCA protonation during ATP hydrolysis; extends biochemical models but leaves open in vivo cardiac relevance.
The study provides biochemical evidence that protonation of the sarcoplasmic reticulum Ca-ATPase occurs inside vesicles during ATP hydrolysis, supporting the mechanism of H+ counter-transport coupled to Ca2+ uptake.
Yamaguchi et al. (1984) studied this question.
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