What question did this study set out to answer?

To assess how protein energy malnutrition affects arginase expression in monocytes and macrophages and evaluate its role in susceptibility to infection.

October 24, 2014Nutrition & MetabolismOpen Access

Protein energy malnutrition increases arginase activity in monocytes and macrophages

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Authors

KCKarina Corware VYVanessa Yardley CMChristopher P. Mack

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Overview

Experimental study reveals increased myeloid arginase activity in malnourished mice, suggesting a metabolic driver of vulnerability to infectious disease.

Key Points

To assess how protein energy malnutrition affects arginase expression in monocytes and macrophages and evaluate its role in susceptibility to infection.
Evaluated bone marrow and blood monocytes and macrophages in mice maintained on a low-protein diet.
Assayed bone marrow-derived macrophages in vitro for phagocytic activity, nitric oxide synthesis, and intracellular killing of Leishmania parasites.
Quantified splenic parasite burden and arginase activity using an in vivo murine model of visceral leishmaniasis.
Mice receiving a low-protein diet showed significantly increased populations of monocytes and macrophages in both bone marrow and blood.
Macrophage phagocytosis, nitric oxide production, and parasite clearance remained intact, but arginase expression was significantly elevated both in vitro and in vivo.
Malnourished mice with visceral leishmaniasis demonstrated increased splenic parasite burdens that coincided with elevated arginase activity, fostering a permissive environment for pathogen replication.

Cite This Study

Corware et al. (2014) studied this question.

synapsesocial.com/papers/6aa39e2cd5ccfe0ebfb71e47 https://doi.org/10.1186/1743-7075-11-51

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October 24, 2014Nutrition & MetabolismOpen Access

Protein energy malnutrition increases arginase activity in monocytes and macrophages

View Full Paper

Ask AI

Bookmark

Authors

KCKarina Corware VYVanessa Yardley CMChristopher P. Mack

Discussion

Member takes

Overview

Experimental study reveals increased myeloid arginase activity in malnourished mice, suggesting a metabolic driver of vulnerability to infectious disease.

Key Points

To assess how protein energy malnutrition affects arginase expression in monocytes and macrophages and evaluate its role in susceptibility to infection.
Evaluated bone marrow and blood monocytes and macrophages in mice maintained on a low-protein diet.
Assayed bone marrow-derived macrophages in vitro for phagocytic activity, nitric oxide synthesis, and intracellular killing of Leishmania parasites.
Quantified splenic parasite burden and arginase activity using an in vivo murine model of visceral leishmaniasis.
Mice receiving a low-protein diet showed significantly increased populations of monocytes and macrophages in both bone marrow and blood.
Macrophage phagocytosis, nitric oxide production, and parasite clearance remained intact, but arginase expression was significantly elevated both in vitro and in vivo.
Malnourished mice with visceral leishmaniasis demonstrated increased splenic parasite burdens that coincided with elevated arginase activity, fostering a permissive environment for pathogen replication.

Cite This Study

Corware et al. (2014) studied this question.

synapsesocial.com/papers/6aa39e2cd5ccfe0ebfb71e47 https://doi.org/10.1186/1743-7075-11-51

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