Key result
Nitric oxide inhibition with L-NNA amplifies the serotonin-induced increase in cerebral artery resistance by ~115%.
Absolute Event Rate: 0.43% vs 0.2%
p-value: p=<0.05
Inhibition of nitric oxide formation significantly increases the constrictor response of large cerebral arteries to serotonin in vivo, indicating that EDRF modulates cerebral vasoconstrictor stimuli.
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NO inhibition amplifies serotonin-induced cerebral artery constriction in rabbits; leaves open EDRF modulation of human cerebrovascular responses.
Faraci et al. (1992) studied this question. NG-nitro-L-arginine (L-NNA) vs. Control conditions was evaluated on Change in resistance of large arteries in response to serotonin (p=<0.05). Inhibition of nitric oxide formation with L-NNA more than doubled the increase in large cerebral artery resistance in response to serotonin (0.43 vs 0.20 mm Hg ml-1 min 100 g, p<0.05).
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