All articles of this category In situ N -alkylation of azlactones (1,3-oxazol-5(4 H )-ones) with reactive alkylating agents has been successfully accomplished. The resulting mesoionic 1,3-oxazolium 5-oxides (munchnones) are further transformed into N -alkylated pyrroles via a 1,3-dipolar cycloaddition reaction with a dipolarophile (dimethyl acetylenedicarboxylate) in the presence of 2,6-di- tert -butylpyridine.
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Hershenson et al. (1988) studied this question.