Effect of advancing age on cardiopulmonary baroreceptor function in hypertensive men.
Key result
Older hypertensive men show preserved forearm vascular and norepinephrine responses to cardiopulmonary baroreceptor unloading.
- n=28
Why the study?
Does advancing age affect cardiopulmonary baroreceptor function and sympathetic nervous system activity in hypertensive men?
Population
28 hypertensive men with mild to moderate hypertension, comprising 15 younger than 55 years and 13 older…
Comparison
Graded lower body negative pressure vs Younger hypertensive men compared to older…
Design
Cross-sectional
Authors
Discussion
Loading...
Member takes
Implication
Preserved baroreflex responses with age should not yet change hypertension management; leaves open longitudinal confirmation in broader cohorts.
Study Design
Type
Cross-Sectional (n=28)
Structured PICO
Does advancing age affect cardiopulmonary baroreceptor function and sympathetic nervous system activity in hypertensive men?
P
Population
28 hypertensive men, divided into younger (<55 years) and older (>55 years) cohorts, evaluated for cardiopulmonary baroreceptor function.
E
Exposure
Graded lower body negative pressure (selective unloading of low pressure cardiopulmonary baroreceptors)
C
Comparator
Younger hypertensive men (<55 years) compared to older hypertensive men (>55 years)
O
Outcome
Blood pressure, heart rate, forearm vascular resistance, and hormonal (norepinephrine) responsessurrogate
Normal vascular responses to the unloading of cardiopulmonary baroreceptors are preserved with advancing age in men with mild to moderate hypertension, without an age-related increase in sympathetic nervous system activity.
Cite This Study
Sowers et al. (1987) conducted a cross-sectional in Hypertension (n=28). Advancing age (>55 years) vs. Younger age (<55 years) was evaluated on Forearm vascular resistance and hormonal responses to graded lower body negative pressure. Advancing age in hypertensive men was associated with preserved forearm vascular resistance and norepinephrine responses to cardiopulmonary baroreceptor unloading compared to younger men.