Key result
Cardiovascular disease is the leading cause of death in the elderly, but older patients with comorbidities and polypharmacy are typically excluded from clinical trials, limiting treatment applicability.
Population
Elderly population (over 65 years, particularly over 80 years)
Design
Review
Authors
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Trial applicability limited in comorbid elderly; leaves open need for inclusive studies in this population.
Highlights the increasing burden of cardiovascular disease in the elderly and the challenge of applying clinical trial data to older patients with multiple comorbidities.
Michael Lye (2000) conducted a review in Cardiovascular disease. Cardiovascular disease is the leading cause of death in the elderly, but older patients with comorbidities and polypharmacy are typically excluded from clinical trials, limiting treatment applicability.
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