Key result
Major surgical trauma in pigs reduces whole body glucose disposal by ~45%.
Population
Anesthetized pigs (n=8 per experimental phase)
Comparison
Hyperinsulinemic euglycemic step clamping with… vs Baseline (before surgical instrumentation)
Design
Preclinical
Authors
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Validates step hot-GINF HEC for acute insulin resistance in porcine surgical models; leaves open translation to human perioperative care.
Step hot-GINF HEC is a suitable method for assessing acute insulin resistance in anesthetized pigs, even when combined with invasive surgical instrumentation.
Gjessing et al. (2010) studied Acute insulin resistance (n=8). Hyperinsulinemic euglycemic step clamping (step hot-GINF HEC) vs. Before surgical instrumentation was evaluated on Whole body glucose disposal and endogenous glucose release. Major surgical trauma in anesthetized pigs evaluated by step hot-GINF HEC elicited 45% lower whole body glucose disposal and 19% less suppressed endogenous glucose release.
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