Key result
T1DM in pregnancy is linked to ~27% lower odds of vaginal delivery versus GDM.
Why the study?
Differences in pregnancy complications, delivery characteristics, and neonatal outcomes among women with T1DM, T2DM, and GDM required examination.
Do maternal and fetal outcomes differ between pregnant women with T1DM, T2DM, and GDM?
Observational (n=6,737)
Do maternal and fetal outcomes differ between pregnant women with T1DM, T2DM, and GDM?
Odds Ratio: 0.73 (95% CI 0.64–0.83)
Pregnant women with T1DM face different complication profiles compared to those with GDM, including higher risks of chronic hypertension and preterm delivery, but lower risks of gestational hypertension.
T1DM pregnancies show distinct risk profiles versus GDM; observational data leave causal mechanisms and practice implications open.
The aim of this study was to examine the differences in pregnancy complications, delivery characteristics, and neonatal outcomes between women with type 1 diabetes mellitus (T1DM), type 2 diabetes mellitus (T2DM), and gestational diabetes mellitus (GDM). This study included all pregnant women with diabetes in pregnancy in Belgrade, Serbia, between 2010 and 2020. The total sample consisted of 6737 patients. In total, 1318 (19.6%) patients had T1DM, 138 (2.0%) had T2DM, and 5281 patients (78.4%) had GDM. Multivariate logistic regression with the type of diabetes as an outcome variable showed that patients with T1DM had a lower likelihood of vaginal delivery (OR: 0.73, 95% CI: 0.64-0.83), gestational hypertension (OR: 0.47, 95% CI: 0.36-0.62), higher likelihood of chronic hypertension (OR: 1.88, 95% CI: 1.55-2.29),and a higher likelihood ofgestational age at delivery before 37 weeks (OR: 1.38, 95% CI: 1.18-1.63) compared to women with GDM. Multivariate logistic regression showed that patients with T2DM had a lower likelihood ofgestational hypertension compared to women with GDM (OR: 0.37, 95% CI: 0.15-0.92).Our results indicate that the highest percentage of diabetes in pregnancy is GDM, and the existence of differences in pregnancy complications, childbirth characteristics, and neonatal outcomes are predominantly between women with GDM and women with T1DM.
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Gojnić et al. (2022) conducted an observational in Diabetes in pregnancy (n=6,737). Type 1 diabetes mellitus vs. Gestational diabetes mellitus was evaluated on Vaginal delivery (OR 0.73, 95% CI 0.64-0.83). Compared to women with gestational diabetes, pregnant women with type 1 diabetes had a lower likelihood of vaginal delivery (OR 0.73; 95% CI 0.64-0.83) and gestational hypertension.
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