Key result
AT1 antagonists reverse Angiotensin II-induced down-regulation of vascular NP-C receptor expression in hypertensive rats.
Population
Stroke-prone spontaneously hypertensive rats (SHR-SP/Izm) and cultured aortic smooth muscle cells
Comparison
Angiotensin II receptor antagonist or calcium… vs Control WKY/Izm rats; untreated cultured cells
Design
Preclinical
Authors
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Ang II-AT1 signaling may alter vascular NP-C expression in hypertension; leaves open any role in human disease or AT1 antagonist effects.
Vascular NP-C receptor is down-regulated via an Ang-II-mediated mechanism in hypertensive rats, which may play a role in counteracting hypertension when combined with NP-A receptor up-regulation.
Takanobu Yoshimoto (1996) studied Hypertension. Angiotensin II receptor (AT1) antagonist (TCV-116 / CV-11974) vs. Control WKY/Izm rats / calcium channel blocker (manidipine) was evaluated on NP-C receptor mRNA level. Angiotensin II down-regulates vascular NP-C receptor mRNA expression in stroke-prone spontaneously hypertensive rats, an effect reversed by an AT1 antagonist.
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