March 1, 1996EndocrinologyOpen Access

Angiotensin II-dependent down-regulation of vascular natriuretic peptide type C receptor gene expression in hypertensive rats.

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Population

Stroke-prone spontaneously hypertensive rats (SHR-SP/Izm) and cultured aortic smooth muscle cells

Comparison

Angiotensin II receptor antagonist and… vs Control WKY/Izm rats, calcium channel blocker…

Design

Preclinical

Authors

TYTakanobu YoshimotoKishokai Medical Corporation MNMitsuhide NarusePreventive Cardiology KNKiyoko NaruseAtlas Scientific (United States)

Discussion

Member takes

Implication

May implicate Ang II in vascular NP-C downregulation in hypertension; leaves open translation to human disease or therapy.

Structured PICO

Population

Stroke-prone spontaneously hypertensive rats (SHR-SP/Izm) and cultured aortic smooth muscle cells

Intervention

Angiotensin II receptor (AT1) antagonist (TCV-116 in vivo, CV-11974 in vitro) and Angiotensin II (in vitro)

Comparator

Control WKY/Izm rats, calcium channel blocker (manidipine), or untreated cells

Outcome

NP-C receptor mRNA level in aortic tissue and cultured cellssurrogate

Vascular NP-C receptor is down-regulated via an Ang-II-mediated mechanism in hypertensive rats, which may play a role in counteracting hypertension when combined with NP-A receptor up-regulation.

Cite This Study

Yoshimoto et al. (1996) studied this question.

synapsesocial.com/papers/6a78dac677336a1bae02023d https://doi.org/10.1210/endo.137.3.8603580

Topics

Hypertension management

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Angiotensin II-dependent down-regulation of vascular natriuretic peptide type C receptor gene expression in hypertensive rats.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Angiotensin II-dependent down-regulation of vascular natriuretic peptide type C receptor gene expression in hypertensive rats.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider