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September 7, 2018JAMA CardiologyOpen Access

Pregnancy after TGA arterial switch proves well tolerated with 0 adverse maternal cardiac events.

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Why the study?

Are there adverse maternal cardiac events or progression of aortic disease during pregnancy in women with transposition of the great arteries after an arterial switch operation?

Population

15 women aged 16 years or older with transposition of the great arteries after an arterial switch operation…

Design

Cohort

Follow-up

first year post-partum

Key result

Pregnancy was well tolerated in women with previous arterial switch surgery for transposition of the great arteries, with 0 adverse maternal cardiac events observed across 25 pregnancies.

Authors

VSVictoria StollNDNigel E DrurySTSara Thorne

Discussion

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Overview

Supports counseling on pregnancy after arterial switch; leaves open confirmation in larger prospective cohorts.

Study Design

Type

Cohort (n=15)

Multicenter

No

Structured PICO

Are there adverse maternal cardiac events or progression of aortic disease during pregnancy in women with transposition of the great arteries after an arterial switch operation?

P
Population
15 women aged 16 years or older with previous arterial switch surgery for transposition of the great arteries and a completed or ongoing pregnancy.
E
Exposure
Pregnancy
O
Outcome
Adverse maternal cardiac events (arrhythmia, heart failure, aortic dissection, or acute coronary syndrome) and aortic root dilatation, aortic regurgitation, and left ventricular function before and after pregnancysafety

Pregnancy is well tolerated in women with transposition of the great arteries after an arterial switch operation, without adverse maternal cardiac events or early progression of neoaortic root dilatation.

Cite This Study

Stoll et al. (2018) conducted a cohort in Transposition of the great arteries after an arterial switch operation (n=15). Pregnancy was evaluated on Adverse maternal cardiac events (arrhythmia, heart failure, aortic dissection, or acute coronary syndrome). Pregnancy was well tolerated in women with previous arterial switch surgery for transposition of the great arteries, with 0 adverse maternal cardiac events observed across 25 pregnancies.

synapsesocial.com/papers/6aa4c67810877e4fda94e6bchttps://doi.org/10.1001/jamacardio.2018.2747
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Outcome of Pregnancy in Women With D‐Transposition of the Great Arteries: A Systematic Review2022 · 12 citations
  2. 2Obstetric outcomes following atrial and arterial switch procedures for transposition of the great arteries (TGA) – A single, tertiary referral centre experience over 20 years2019 · 5 citations
  3. 3Arterial switch and neurological outcomes: a retrospective study of medical records2025 · 1 citations
  4. 4Echocardiographic Midterm and Long-term Outcomes After Arterial Switch Operation for d-Transposition of the Great Arteries: A Single-Institution Experience2022
  5. 5Neo-Aortic Root Dilation in Pregnancy After Arterial Switch for Complete Transposition of the Great Arteries2026