Key result
Arterial switch linked to ~66% lower prematurity rate vs atrial switch in d-TGA pregnancy.
Why the study?
Information on maternal and fetal outcomes of pregnancy in women with D-transposition of the great arteries is limited.
What are the maternal and fetal outcomes of pregnancy in women with D-transposition of the great arteries after arterial versus atrial switch operations?
Systematic Review (n=444)
What are the maternal and fetal outcomes of pregnancy in women with D-transposition of the great arteries after arterial versus atrial switch operations?
Absolute Event Rate: 11% vs 32%
p-value: p=<0.001
Pregnancy is generally well-tolerated in women with D-TGA, but those with prior arterial switch operations have significantly more favorable maternal and fetal outcomes compared to those with atrial switch operations.
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Supports arterial switch consideration in D-TGA pregnancy counseling; extends observational comparisons to fetal outcomes.
Pizula et al. (2022) conducted a systematic review in D-transposition of the great arteries (n=444). Arterial switch operation (ASO) vs. Atrial switch operation (ATSO) was evaluated on Prematurity (p=<0.001). In pregnant women with D-transposition of the great arteries, prior arterial switch operation was associated with a significantly lower rate of prematurity (11% vs 32%, p<0.001) and no maternal mortality compared to atrial switch operation.
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