Key result
Pindolol added to methyldopa is linked to an ~18 mmHg drop in supine systolic BP.
Why the study?
Does concomitant treatment with pindolol improve blood pressure control and allow methyldopa dose reduction in hypertensive patients inadequately controlled or experiencing side-effects with methyldopa?
Does concomitant treatment with pindolol improve blood pressure control and allow methyldopa dose reduction in hypertensive patients inadequately controlled or experiencing side-effects with methyldopa?
The addition of pindolol effectively lowers blood pressure and allows for a reduction or discontinuation of methyldopa in patients with inadequately controlled hypertension.
Answers are grounded in this paper and cite their sources.
May support pindolol add-on for control and methyldopa sparing; leaves open need for randomized confirmation.
SummaryAn open study was carried out in 50 hypertensive patients, inadequately controlled or experiencing side-effects with methyldopa, to assess the effects of concomitant treatment with pindolol. In the 41 patients completing the trial, mean supine blood pressures were reduced from 177 j 108 mmHg to 159/96 mmHg after 12 weeks of pindolol therapy {mean dose 33 mg/day). Mean methyldopa dosage was reduced from 921 mg to 445 mg daily by the end of the trial, and 14 patients were able to stop methyldopa therapy completely. Three of the 9 patients who withdrew did so because of side-effects, but overall fewer side-effects were reported as the trial continued, and 15 patients commented that they felt better on pindolol.
No takes yet. Share an insight, caveat, or question.
Jane E. Murphy (1977) studied Hypertension (n=50). Pindolol was evaluated on mean supine blood pressure. Concomitant treatment with pindolol for 12 weeks reduced mean supine blood pressure from 177/108 mmHg to 159/96 mmHg in hypertensive patients inadequately controlled on methyldopa.
Synapse has enriched 10 related papers. Consider them for comparative context: