Key result
Cardiac manifestations like tamponade or MI can be the first sign of acute lymphoblastic leukemia.
Why the study?
Cardiac symptoms or signs as the initial manifestation of acute lymphoblastic leukemia are sporadically reported, leading to misdiagnosis or delayed diagnosis due to lack of clinical experience.
What are the clinical features, diagnosis procedures, treatments, and outcomes of acute lymphoblastic leukemia presenting initially as cardiac problems?
Population
30 lymphoblastic leukemia cases initially presenting with cardiac problems
Design
Systematic review
Authors
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Prompt leukemia evaluation is warranted for unexplained cardiac tamponade or masses; extends documented spectrum of initial ALL presentations.
Systematic Review (n=30)
What are the clinical features, diagnosis procedures, treatments, and outcomes of acute lymphoblastic leukemia presenting initially as cardiac problems?
Acute lymphoblastic leukemia can rarely present initially with cardiac symptoms, requiring high clinical suspicion to avoid misdiagnosis and delayed treatment.
Luo et al. (2022) conducted a systematic review in Acute lymphoblastic leukemia with cardiac manifestations (n=30). Systemic chemotherapy and cardiac symptom management was evaluated on Clinical characteristics, diagnostic procedures, and treatment outcomes. Cardiac manifestations such as tamponade, mass, hypertrophy, or myocardial infarction can be the first sign of acute lymphoblastic leukemia, requiring bone marrow biopsy for definitive diagnosis and prompt chemotherapy.
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