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February 1, 1992HypertensionOpen Access

Pressure-induced constriction of the afferent arteriole of spontaneously hypertensive rats.

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Key result

Hypertensive rat afferent arterioles constrict to ~42% narrower diameters than controls at 140 mm Hg.

Population

Single afferent arterioles microdissected from kidneys of spontaneously hypertensive rats and normotensive…

Comparison

Stepwise increase in perfusion pressure from 20… vs Normotensive Wistar-Kyoto (WKY) rats

Design

Preclinical

Authors

SISadayoshi ItoLJLuis A. JuncosOCOscar A. Carretero

Discussion

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Overview

Suggests afferent arteriolar hyperconstriction sustains SHR hypertension; leaves open relevance to human essential hypertension.

Structured PICO

P
Population
In vitro study of single afferent arterioles microdissected from kidneys of spontaneously hypertensive rats (SHRs) and normotensive control Wistar-Kyoto (WKY) rats.
E
Exposure
Stepwise increase in perfusion pressure from 20 to 140 mm Hg in vitro
C
Comparator
Normotensive Wistar-Kyoto (WKY) rats
O
Outcome
Luminal diameter of the afferent arteriolesurrogate

Main Result

Absolute Event Rate: 11.1% vs 19.2%

Exaggerated pressure-induced constriction in the afferent arterioles of spontaneously hypertensive rats may contribute to the development and maintenance of hypertension.

Cite This Study

Ito et al. (1992) studied Hypertension. Spontaneously hypertensive rat (SHR) model vs. Normotensive Wistar-Kyoto (WKY) rats was evaluated on Luminal diameter of afferent arteriole at 140 mm Hg perfusion pressure. At 140 mm Hg perfusion pressure, afferent arterioles from spontaneously hypertensive rats constricted significantly more than normotensive controls (11.1 vs 19.2 microns).

synapsesocial.com/papers/6aa501bdc19a1092ac8126d5https://doi.org/10.1161/01.hyp.19.2_suppl.ii164
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pressure-induced vasoconstriction of renal microvessels in normotensive and hypertensive rats. Studies in the isolated perfused hydronephrotic kidney.1989 · 123 citations
  2. 2Exaggerated renal vascular reactivity to angiotensin and thromboxane in young genetically hypertensive rats1990 · 92 citations
  3. 3Effect of angiotensin II and norepinephrine on isolated rat afferent and efferent arterioles1990 · 130 citations
  4. 4Attenuation of enhanced tubuloglomerular feedback activity in SHR by renal denervation1990 · 38 citations
  5. 5Renal sympathetic activity in spontaneously hypertensive rats and normotensive controls, as studied by three different methods1984 · 141 citations