Key result
Psychological intervention cuts mental stress ~23% vs standard care after PCI, improving cortisol and IL-2.
Why the study?
Does a psychological intervention programme improve mental state, coping style, and immune function in patients undergoing PCI?
RCT (n=60)
Single-blind
Random sequence number generation
No
Does a psychological intervention programme improve mental state, coping style, and immune function in patients undergoing PCI?
Absolute Event Rate: 132.73% vs 172.57%
p-value: p=<0.01
A psychological intervention program consisting of cognitive therapy, relaxation, and emotional support improves mental state and physiological stress markers in PCI patients with anxiety and depression.
Supports integrating psychological interventions into PCI pathways; extends RCT evidence for stress reduction improving immune markers.
PURPOSE: This study aimed to assess the effects of a psychological intervention programme on the mental stress, coping style and cortisol and IL-2 levels of patients undergoing percutaneous coronary intervention (PCI). METHODS: A total of sixty cardiovascular patients scheduled for PCI with clear anxiety and depression screened by the Hospital Anxiety and Depression Scale were randomly divided into an experimental (n = 30) and control (n = 30) group. The participants in the experimental group received cognitive therapy, relaxation therapy and emotional support. Self-reported questionnaires, including the Self-Report Symptom Checklist (SCL-90) and the Medical Coping Mode Questionnaire (MCMQ), and levels of IL-2 and cortisol were collected at baseline and the day before discharge. RESULTS: Compared with the controls, patients in the intervention group had a better mental state and coping style (confrontation), higher levels of IL-2 and lower levels of cortisol (all P<0.05). CONCLUSIONS: The psychological intervention programme effectively improved mental state, reduced negative coping styles, increased levels of IL-2, and decreased cortisol levels in patients undergoing PCI. This programme may be an effective preoperative nursing intervention for PCI patients. TRIAL REGISTRATION: Chinese Clinical Trail Registry ChiCTR-IOR-16007864.
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Zhu et al. (2018) conducted an RCT in Coronary artery disease requiring percutaneous coronary intervention with anxiety and depression (n=60). Psychological intervention programme (cognitive therapy, relaxation therapy, emotional support) vs. Standard care was evaluated on Mental stress (SCL-90 total score) (p=<0.01). A psychological intervention programme significantly reduced mental stress and cortisol levels while increasing IL-2 levels compared to standard care in patients undergoing percutaneous coronary intervention.
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