July 26, 2007Fundamental and Clinical Pharmacology
Association between antipsychotic drugs, antidepressant drugs and venous thromboembolism: results from the EDITH case–control study
Key result
Current antipsychotics linked to ~250% higher VTE risk, while antidepressants show no association.
- OR 3.5
- 95% CI 2.0-6.2
- n=1,354
Why the study?
Does exposure to antipsychotic or antidepressant drugs increase the risk of venous thromboembolism?
Population
1,354 patients, comprising 677 cases hospitalized with deep vein thrombosis and/or pulmonary embolism with…
Comparison
Current use of neuroleptic or antidepressant… vs Non-use of neuroleptic or antidepressant drugs.
Design
Case-control
Authors
Discussion
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Member takes
Implication
May heighten VTE vigilance with antipsychotics; leaves open causality and needs prospective confirmation.
Study Design
Type
Case-Control (n=1,354)
Structured PICO
Does exposure to antipsychotic or antidepressant drugs increase the risk of venous thromboembolism?
P
Population
1,354 patients, comprising 677 cases hospitalized with VTE without major acquired risk factors and 677 age- and gender-matched controls.
E
Exposure
Current use of neuroleptic (antipsychotic) or antidepressant drugs at admission.
C
Comparator
Non-use of neuroleptic or antidepressant drugs (matched controls).
O
Outcome
Venous thromboembolism (deep vein thrombosis and/or pulmonary embolism).hard clinical
Main Result
Odds Ratio: 3.5 (95% CI 2–6.2)
Exposure to antipsychotic drugs, but not antidepressants, is associated with a significantly increased risk of venous thromboembolism, suggesting clinicians should consider it a potential risk factor.
Cite This Study
Lacut et al. (2007) conducted a case-control in Venous thromboembolism (n=1,354). Antipsychotic and antidepressant drugs vs. Non-use was evaluated on Venous thromboembolism (OR 3.5, 95% CI 2.0-6.2). Current exposure to antipsychotic agents was associated with an increased risk of venous thromboembolism (OR 3.5; 95% CI 2.0-6.2), whereas antidepressant exposure showed no association.