Key result
Atenolol reduces blood pressure and platelet adhesion vs placebo but lowers HDL cholesterol.
Why the study?
Does atenolol 100 mg/day reduce blood pressure and platelet adhesion in patients with established hypertension?
Population
14 patients with established hypertension
Comparison
Atenolol 100 mg/day vs Placebo
Design
RCT, double-blind
Authors
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Supports atenolol for hypertension with platelet benefits; extends RCT data on its HDL-lowering effects.
RCT (n=14)
Double-blind
Does atenolol 100 mg/day reduce blood pressure and platelet adhesion in patients with established hypertension?
Atenolol effectively lowers blood pressure and reduces platelet adhesion in hypertensive patients, which may contribute to its cardioprotective effects, though it lowers HDL cholesterol.
Markel et al. (1983) conducted an RCT in Hypertension (n=14). Atenolol vs. Placebo was evaluated on Platelet adhesion and aggregation. Atenolol 100 mg/day significantly reduced blood pressure and platelet adhesion in hypertensive patients compared to placebo, but also caused a significant fall in HDL cholesterol.
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