Key result
Fluorescent probe indo-1 detects intracellular calcium transients in isolated ventricular cells without altering mechanical performance.
The fluorescent probe indo-1 allows for the simultaneous measurement of calcium transients and cellular motion in isolated ventricular cells without causing significant alterations in mechanical performance.
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Supports dual Ca2+ and motion measurements in isolated myocytes; leaves open extension to mammalian or in vivo models.
Peeters et al. (1987) studied Cultured chick embryo ventricular cells (n=8). indo-1-acetoxymethyl ester (indo-1 AM) vs. Control levels (before loading or after wash) was evaluated on Intracellular calcium concentration transients and motion. The fluorescent Ca2+ probe indo-1 can detect intracellular calcium transients in isolated ventricular cells without causing significant alterations in mechanical performance.
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