Key result
Obesity is linked to ~10% lower LVEF 7-9 days post-STEMI compared to normal weight.
Why the study?
High BMI is often associated with metabolic syndrome and systemic low-grade chronic inflammation, but whether these factors and inflammatory markers correlate with left ventricular geometry, function, and infarct size after a first STEMI was unclear.
Population
91 patients with a first clinically evident STEMI
Comparison
BMI, components of metabolic syndrome, and inflammatory markers
Design
Longitudinal cohort study
Follow-up
12 months
Authors
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Obesity may flag higher risk of early LV impairment post-STEMI; leaves open whether BMI independently predicts outcomes or warrants intervention.
Cohort (n=91)
Absolute Event Rate: 45.8% vs 56.2%
p-value: p=<0.001
Metabolic syndrome components such as BMI and HbA1c predict early left ventricular dysfunction after STEMI, while peak CRP is a strong independent predictor of both early and late left ventricular function.
Traub et al. (2022) conducted a cohort in First ST-elevation myocardial infarction (STEMI) (n=91). Overweight and obesity (high BMI) vs. Normal weight was evaluated on Left ventricular ejection fraction (LVEF) 7-9 days after STEMI (p=<0.001). Obese and overweight patients had significantly lower left ventricular ejection fraction 7-9 days post-STEMI compared to normal weight patients (45.8% and 49.5% vs 56.2%; P<0.001 for BMI).
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