Key result
Neutrophil lymphocyte ratio was significantly higher in type 2 diabetes patients with coronary artery disease compared to those without coronary artery disease (2.76 vs. 1.56, p<0.001).
Why the study?
Is elevated neutrophil lymphocyte ratio associated with the presence of coronary artery disease in patients with type 2 diabetes mellitus?
Case-Control (n=134)
No
Is elevated neutrophil lymphocyte ratio associated with the presence of coronary artery disease in patients with type 2 diabetes mellitus?
Elevated neutrophil-lymphocyte ratio is associated with the presence of significant coronary artery disease in patients with type 2 diabetes mellitus, suggesting its potential utility as an inflammatory marker for atherosclerosis.
Background: Increased neutrophil lymphocyte ratio is associated with major adverse outcomes of cardiac events in type 2 diabetes mellitus (DM) patients.Objective: To assess the NLR as an inflammatory marker in atherosclerosis in type 2 DM patients with coronary artery disease (CAD).Methods: This case control study was conducted in the Department of Clinical Pathology in collaboration with Department of Cardiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, from March 2014 to February 2015. Total 134 patients were enrolled in this study who were waiting for coronary angiography in the Department of Cardiology, BSMMU; 84 cases were considered as Group I (DM with CAD) and 50 controls were Group II (DM without CAD). A 2 ml of blood was collected in EDTA tube from the patients prior to coronary angiogram for complete blood count (CBC) were measured by haematology autoanalyzer, rechecked manually and NLR was calculated in the Department of Clinical Pathology, BSMMU. Coronary artery disease with 50% coronary artery stenosis and more critical lesion that were diagnosed by coronary angiography were included in this study as cases. Coronary artery disease with less than 50% coronary artery stenosis that was diagnosed by coronary angiography was included in this study as control.Results: NLR was higher in CAD positive group compared to group without CAD negative in type 2 DM patients (2.76 (±0.74) vs. 1.56 (±0.15), p<0.001).Conclusion: With the help of neutrophil lymphocyte ratio we can take preventive measure and precaution to reduce the progression of atherosclerosis in type 2 diabetic patients with coronary artery disease.J Dhaka Medical College, Vol. 24, No.1, April, 2015, Page 24-29
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Bhuiyan et al. (2016) conducted a case-control in Type 2 diabetes mellitus with coronary artery disease (n=134). Coronary artery disease (≥50% stenosis) vs. No coronary artery disease (<50% stenosis) was evaluated on Neutrophil lymphocyte ratio (NLR) (p=<0.001). Neutrophil lymphocyte ratio was significantly higher in type 2 diabetes patients with coronary artery disease compared to those without coronary artery disease (2.76 vs. 1.56, p<0.001).
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