What is the clinical evidence from this study?

Population: Hemorrhagic shock. Intervention: NG-monomethyl-L-arginine (L-NMMA) vs. Controls. Primary outcome: 48-h survival rate (p=< 0.05).

What does this research mean for the field?

Low-dose nitric oxide synthase inhibition with L-NMMA improves hemodynamics, reduces organ damage, and significantly increases survival in hemorrhagic shock, whereas high doses are deleterious. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the role of nitric oxide in cardiovascular collapse, multiple organ damage, and mortality resulting from prolonged hemorrhagic shock.

May 1, 1996AJP Heart and Circulatory Physiology

Significance of NO in hemorrhage-induced hemodynamic alterations, organ injury, and mortality in rats

Q: What are the key findings of this study?

Infusion of 2.0 mg/kg L-NMMA significantly improved the 48-h survival rate from 26.7% to 68.8% in rats subjected to hemorrhagic shock (P < 0.05), whereas a 20.0 mg/kg dose was deleterious.

Q: What does this research mean for the field?

Low-dose nitric oxide synthase inhibition with L-NMMA improves hemodynamics, reduces organ damage, and significantly increases survival in hemorrhagic shock, whereas high doses are deleterious. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Q: What question did this study set out to answer?

To evaluate the role of nitric oxide in cardiovascular collapse, multiple organ damage, and mortality resulting from prolonged hemorrhagic shock.

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Key result

Low-dose L-NMMA boosts survival to ~69% in rats with hemorrhagic shock, whereas high doses harm.

P<0.05

Why the study?

Does L-NMMA improve hemodynamics and survival in rats subjected to hemorrhagic shock?

Population

Anesthetized rats subjected to prolonged hypovolemic insult (hemorrhagic shock, 30-35 mmHg for 180 min)

Comparison

NG-monomethyl-L-arginine infusion at 2.0 mg/kg… vs Control group

Design

Preclinical

Follow-up

48 hours

Authors

YYYong-ming YaoChinese PLA General Hospital SBSahar Nikkhah BahramiTehran University of Medical Sciences GLGünther LeichtfriedLudwig Boltzmann Institute for Experimental and Clinical Traumatology

Discussion

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Implication

Low-dose L-NMMA may enhance survival in rat hemorrhagic shock models; leaves open translation to human resuscitation.

Key Points

To evaluate the role of nitric oxide in cardiovascular collapse, multiple organ damage, and mortality resulting from prolonged hemorrhagic shock.
Anesthetized rats were subjected to prolonged hypovolemic shock with mean arterial pressure held at 30–35 mmHg for 180 minutes.
Following resuscitation, rats received either low-dose (2.0 mg/kg) or high-dose (20.0 mg/kg) L-NMMA, a nitric oxide synthase inhibitor, compared with controls.
Low-dose L-NMMA (2.0 mg/kg) improved mean arterial pressure, cardiac index, and stroke volume, while reducing organ damage and increasing 48-hour survival from 26.7% to 68.8% (P < 0.05).
High-dose L-NMMA (20.0 mg/kg) increased peripheral resistance and blood pressure but caused marked reductions in cardiac index and stroke volume with increased organ injury at 2 hours.
Hemorrhagic shock insult caused significant concurrent elevations in both circulating endotoxin and tumor necrosis factor levels.

Structured PICO

Does L-NMMA improve hemodynamics and survival in rats subjected to hemorrhagic shock?

Population

Anesthetized rats subjected to prolonged hypovolemic insult to evaluate the role of nitric oxide in hemorrhagic shock.

Intervention

NG-monomethyl-L-arginine (L-NMMA) infusion at 2.0 mg/kg or 20.0 mg/kg at the end of resuscitation

Comparator

Control group

Outcome

Hemodynamic alterations (mean arterial pressure, cardiac index, stroke volume), multiple organ damage, and 48-h survival ratehard clinical

Main Result

Absolute Event Rate: 68.8% vs 26.7%

p-value: p=< 0.05

In a rat model of hemorrhagic shock, low-dose NO synthase inhibition with L-NMMA improves hemodynamics and survival, whereas high-dose administration is deleterious.

Cite This Study

Yao et al. (1996) studied Hemorrhagic shock. NG-monomethyl-L-arginine (L-NMMA) vs. Controls was evaluated on 48-h survival rate (p=< 0.05). Infusion of 2.0 mg/kg L-NMMA significantly improved the 48-h survival rate from 26.7% to 68.8% in rats subjected to hemorrhagic shock (P < 0.05), whereas a 20.0 mg/kg dose was deleterious.

synapsesocial.com/papers/6aa5abda86a9fcb2499228ce https://doi.org/10.1152/ajpheart.1996.270.5.h1616

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Significance of NO in hemorrhage-induced hemodynamic alterations, organ injury, and mortality in rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Significance of NO in hemorrhage-induced hemodynamic alterations, organ injury, and mortality in rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider