Why the study?
Does NO synthesis inhibition with L-NAME improve the hemodynamic response to hemorrhagic shock in dehydrated conscious swine?
Population
Conscious, dehydrated swine undergoing a 37% blood volume hemorrhage
Comparison
N omega-nitro-L-arginine methyl ester 0.75 mg/kg… vs Dehydrated and euhydrated control groups
Design
Preclinical
Follow-up
180 min
Authors
Loading...
L-NAME confers no hemodynamic benefit in this swine shock model; leaves open NO inhibition as a strategy in human resuscitation.
Does NO synthesis inhibition with L-NAME improve the hemodynamic response to hemorrhagic shock in dehydrated conscious swine?
Nitric oxide synthesis inhibition with L-NAME does not provide hemodynamic benefit during hemorrhagic shock in dehydrated conscious swine.
Brown et al. (1995) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: