Key result
Microscopic margin involvement is linked to ~50% higher tumor recurrence in retroperitoneal liposarcoma.
Why the study?
No previously published study had assessed the evolution and oncological prognosis of different subtypes of liposarcoma at the retroperitoneal level compared with other locations.
Does the location of liposarcoma (retroperitoneal vs non-retroperitoneal) affect recurrence and survival?
Observational (n=52)
No
Does the location of liposarcoma (retroperitoneal vs non-retroperitoneal) affect recurrence and survival?
Odds Ratio: 1.5
p-value: p=0.02
Surgical treatment with unaffected margins is the main prognostic factor for survival in liposarcoma, with greater survival observed in extraperitoneal locations for certain histological subtypes.
May inform recurrence risk counseling; leaves open whether wider resection improves outcomes.
Adipocytic tumours are the most common soft tissue neoplasms. Among them, liposarcoma is the most frequent malignant neoplasm. However, to the best of our knowledge, no previously published study has assessed the evolution and oncological prognosis of the different subtypes of liposarcoma at the retroperitoneal level compared with at other locations. The present study is a retrospective observational study in which all patients were operated on between October 2000 and January 2020 with a histological diagnosis of liposarcoma. Variables, such as age, sex, location, histological type, recurrence, type of treatment and mortality, among others, were analysed. The patients were divided into two groups: Group A (retroperitoneal location) and group B (non-retroperitoneal location). A total of 52 patients with a diagnosis of liposarcoma (17 women and 35 men) and a mean age of 57.2±15.9 years were assessed. A total of 16 patients were classified into group A and 36 into group B. The OR of recurrence was 1.5 (P=0.02) for R1 vs. R0 resection in group A. The OR of recurrence in group B for R1 vs. R0 resection was 1.8 (P=0.77), whereas for R2 vs. R0 resection, the OR was 69 (P=0.011). In conclusion, 52 cases of malignant adipocytic tumours collected during 2000-2020 were analysed with the new World Health Organization classification (updated 2020). Although its recurrence potential and capacity for distant metastasis depended on each histological type, surgical treatment with unaffected margins was the main prognostic factor for survival. The present study identified differences in relation to the survival of each histological subtype and its location, finding greater survival in dedifferentiated liposarcoma, myxoid liposarcoma and pleomorphic liposarcoma located at the extraperitoneal level than in the retroperitoneal location. Resectability was not influenced by liposarcoma location.
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Mendoza‐Moreno et al. (2023) conducted an observational in Malignant adipocytic tumours (Liposarcoma) (n=52). Microscopic margin involvement (R1 resection) vs. Unaffected surgical margins (R0 resection) was evaluated on Tumor recurrence in retroperitoneal location (Group A) (OR 1.5, p=0.02). In patients with retroperitoneal liposarcoma, microscopic margin involvement (R1 resection) was significantly associated with increased tumor recurrence compared to unaffected margins (OR 1.5).
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