Key result
Foot-and-mouth disease in cattle linked to ~274% higher serum nitric oxide and increased oxidant capacity.
Why the study?
Does foot-and-mouth disease affect total antioxidant capacity, total oxidant capacity, and nitric oxide levels in cattle?
Case-Control (n=20)
No
Does foot-and-mouth disease affect total antioxidant capacity, total oxidant capacity, and nitric oxide levels in cattle?
Absolute Event Rate: 15.8% vs 4.23%
p-value: p=<0.05
Foot-and-mouth disease in cattle is associated with increased oxidative stress as evidenced by elevated TOC and NO levels.
The aim of this study was to investigate total antioxidant (TAC), oxidant capacity (TOC) and nitric oxide levels (NO) in cattle with foot-and-mouth-diseases (FMD). Twenty Swiss Brown cattle aged between 24 and 48 months were used. Animals were divided into two groups as control (n=10) and FMD (n=10). Blood samples were collected from jugular vein and centrifuged. TOC and NO levels were found to be significantly higher in FMD group compared to those of control group. However, no significant differences were present in TAC levels between FMD and control groups. It was concluded that FMD increases serum NO levels and TOC, but do not affect TAC in cattle.
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Bozukluhan et al. (2012) conducted a case-control in Foot-and-mouth disease (n=20). Foot-and-mouth disease vs. Healthy controls was evaluated on Serum nitric oxide (NO) levels (p=<0.05). Foot-and-mouth disease in cattle significantly increased serum nitric oxide levels (15.80 vs 4.23 mmol/L) and total oxidant capacity compared to healthy controls, without affecting total antioxidant capacity.
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