What does this research mean for the field?

Foot-and-mouth disease virus (strain O1 Lausanne) causes fatal acute myocarditis in piglets without vesicular lesions, while initiation of disease in fattening pigs requires a high infectious dose of log10 4.8 TCID50. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

November 17, 1984Veterinary Record

Experimental foot-and-mouth disease in fattening pigs, sows and piglets in relation to outbreaks in the field

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Key result

Exposure to O1 Lausanne virus caused fatal acute myocarditis without vesicles in most piglets and required a 50% infective dose of log(10)4.8 TCID50 to initiate disease in fattening pigs.

Authors

ADA. DonaldsonFairfield Hospital NFN.P. FerrisThe Pirbright Institute GWG. A. H. WellsVeterinary Medicines Directorate

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Implication

Provides swine model of fatal viral myocarditis without vesicles; leaves open translational relevance to human cardiovascular research.

Key Points

Key points are not available for this paper at this time.

Cite This Study

Donaldson et al. (1984) studied this question. Exposure to O1 Lausanne virus caused fatal acute myocarditis without vesicles in most piglets and required a 50% infective dose of log(10)4.8 TCID50 to initiate disease in fattening pigs.

synapsesocial.com/papers/6aa5b6a2affc7bfe5364b472 https://doi.org/10.1136/vr.115.20.509

Topics

Myocarditis

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Experimental foot-and-mouth disease in fattening pigs, sows and piglets in relation to outbreaks in the field

Discussion

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Implication

Key Points

Cite This Study

Topics

Experimental foot-and-mouth disease in fattening pigs, sows and piglets in relation to outbreaks in the field

Discussion

Member takes

Implication

Key Points

Cite This Study

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