Key result
Plasma fibrinogen yields an adjusted regression dilution ratio of ~0.46.
Population
27,247 adults from 15 prospective studies with repeat measurement data for plasma fibrinogen
Design
Meta-analysis
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Supports using RDR ~0.5 to correct fibrinogen dilution bias in prospective studies; extends estimates to vascular risk factor-adjusted models.
Meta-Analysis (n=27,247)
Yes
Effect estimate: RDR 0.51 (95% CI 0.47, 0.55)
An RDR of 0.5 is appropriate to correct for regression dilution bias in plasma fibrinogen values in prospective studies.
A 2006 study reported a meta-analysis. Plasma fibrinogen was evaluated on Regression dilution ratio (RDR) (RDR 0.51, 95% CI 0.47, 0.55). The unadjusted overall regression dilution ratio for plasma fibrinogen was 0.51 (95% CI: 0.47, 0.55), decreasing to 0.46 (95% CI: 0.42, 0.49) after adjustment for vascular risk factors.
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