Key result
His bundle pacing plus AV junction ablation normalizes QRS and restores exertion in incurable AF.
Why the study?
AV junction ablation and pacing is an option for AF rate control, but right ventricular pacing causes interventricular asynchrony, whereas His pacing restores physiological ventricular activation.
Does simultaneous His bundle pacemaker implantation and AV junction ablation improve symptoms and QRS duration in a patient with incurable atrial fibrillation?
Case Report (n=1)
Does simultaneous His bundle pacemaker implantation and AV junction ablation improve symptoms and QRS duration in a patient with incurable atrial fibrillation?
Simultaneous His bundle pacing and AV junction ablation is a feasible 'ablate-and-pace' strategy for incurable atrial fibrillation that can restore physiological ventricular activation and improve symptoms.
Answers are grounded in this paper and cite their sources.
May support His bundle pacing plus AV ablation for symptom relief in incurable AF; hypothesis-generating and should not yet change practice.
BACKGROUND: Atrial fibrillation can contribute to heart failure. Frequently, rhythm control is unachievable. Atrioventricular (AV) junction ablation and pacemaker implantation remain to be a therapeutic option for rate control in atrial fibrillation. Interventricular asynchrony is a potential downside of right ventricular pacing. However, cardiac resynchronization therapy and His pacing restore physiological activation sequences of the ventricles. CASE SUMMARY: The reported patient had undergone several interventions to cure atrial fibrillation without sufficient rhythm control and experienced deleterious effects of recurrent arrhythmias. Finally, we decided to ablate the AV junction simultaneously with the implantation of a His bundle pacemaker. Atrioventricular junction ablation had to be repeated following conduction recurrence. A left-sided transaortic approach was required to create a permanent effect and to avoid distal lesions. His pacing was not affected by the AV junction ablation at all. The pre-existing widened QRS was normalized by His pacing, the patient became free of any complaints with full restoration of exertion capability. DISCUSSION: His pacing has the potential to contribute to a revival of the 'ablate-and-pace' concept for incurable atrial fibrillation by restoring physiological ventricular activation, thereby overcoming the particular drawbacks of continuous ventricular pacing. Atrioventricular junction ablation simultaneously with the pacemaker implantation procedure is safe and feasible. His pacing is at least an alternative for cardiac resynchronization therapy. The implantation procedure is sometimes challenging.
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Meininghaus et al. (2020) conducted a case report in Atrial fibrillation (n=1). Simultaneous His pacemaker implantation and atrioventricular junction ablation was evaluated on QRS duration and clinical symptoms. Simultaneous His bundle pacemaker implantation and AV junction ablation normalized pre-existing widened QRS and fully restored exertion capability in a patient with incurable atrial fibrillation.
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