Key result
Harmful compensatory mechanisms like neurohormonal activation and ventricular remodeling drive heart failure morbidity and mortality.
Why the study?
Heart failure causes high morbidity, mortality, and financial burden, and further research is needed to identify novel therapeutic targets to improve patient survival.
Design
Review article
Authors
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Novel HF compensation insights may inform therapy development; leaves open clinical translation pending prospective trials.
This review highlights the pathophysiology of heart failure and emphasizes the need for further research to identify novel therapeutic targets.
Wijdan Akram Hussein (2024) conducted a review in Heart Failure. Heart failure is a complex clinical syndrome with high morbidity and mortality, driven by compensatory mechanisms like neurohormonal activation and ventricular remodeling that eventually become harmful.
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