Studies on Immunity to Staphylococcal Infection in Mice*: I. Effect of Dosage, Viability, and Interval between Immunization and Challenge on Resistance to Infection Following Injection of Whole Cell Vaccines

Richard D. Ekstedt

doi:10.1093/infdis/112.2.143

March 1, 1963The Journal of Infectious Diseases

Studies on Immunity to Staphylococcal Infection in Mice*: I. Effect of Dosage, Viability, and Interval between Immunization and Challenge on Resistance to Infection Following Injection of Whole Cell Vaccines

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Key Points

To determine how vaccine dosage, bacterial viability, and the interval between immunization and challenge influence host resistance against staphylococcal infection in mice.
Immunized mice with whole-cell staphylococcal vaccine preparations varying in dose and viability status.
Challenged immunized animals with staphylococcal infection across varying post-immunization intervals to assess protective immunity.
Resistance to staphylococcal challenge varied significantly depending on the administered vaccine dose and the viability of the whole bacterial cells.
The duration of the interval between initial immunization and subsequent bacterial challenge strongly altered protective efficacy.

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Implication

Laboratory animal study reveals how vaccine dose, viability, and timing alter staphylococcal resistance in mice, highlighting key parameters for antibacterial immunity.

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Richard D. Ekstedt (1963) studied this question.

synapsesocial.com/papers/6aa645fb24014aaf7fdd590c https://doi.org/10.1093/infdis/112.2.143

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Studies on Immunity to Staphylococcal Infection in Mice*: I. Effect of Dosage, Viability, and Interval between Immunization and Challenge on Resistance to Infection Following Injection of Whole Cell Vaccines

Key Points

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Implication

Discussion

Cite This Study

Studies on Immunity to Staphylococcal Infection in Mice*: I. Effect of Dosage, Viability, and Interval between Immunization and Challenge on Resistance to Infection Following Injection of Whole Cell Vaccines

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Implication

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