SYNTAX Score and SYNTAX Score II Can Predict the Clinical Outcomes of Patients with Left Main and/or 3-Vessel Disease Undergoing Percutaneous Coronary Intervention in the Contemporary Cobalt-Chromium Everolimus-Eluting Stent Era
View Full Paper
Ask AI
Bookmark
Share
Key result
SYNTAX Score II outperforms the anatomical score in predicting 3-year major events after LM/3VD PCI.
- HR 1.324
- 95% CI 1.095-1.601
- P=0.004
- n=1,248
Why the study?
The impact of the SYNTAX score and SYNTAX score II in patients undergoing PCI with second-generation everolimus-eluting stents had not been fully validated.
Does SYNTAX Score II improve prediction of clinical outcomes compared to the original SYNTAX Score in patients with left main and/or 3-vessel disease undergoing PCI with everolimus-eluting stents?
Population
1,248 patients with left main and/or 3-vessel disease treated with EES
Comparison
SS vs SS II
Design
Cohort study
Follow-up
3 years
Authors
Discussion
Loading...
Member takes
Implication
May support improved risk prediction after complex PCI; leaves open prospective validation before guiding decisions.
Study Design
Type
Cohort (n=1,248)
Multicenter
Yes
Structured PICO
Does SYNTAX Score II improve prediction of clinical outcomes compared to the original SYNTAX Score in patients with left main and/or 3-vessel disease undergoing PCI with everolimus-eluting stents?
P
Population
1,248 patients with left main and/or 3-vessel disease treated with cobalt-chromium everolimus-eluting stents, followed for 36 months.
E
Exposure
Risk stratification using SYNTAX Score II
C
Comparator
Risk stratification using original SYNTAX Score
O
Outcome
Patient-oriented composite endpoint (POCE; all-cause death, any myocardial infarction, any revascularization) and target lesion failure (TLF: cardiac death, target-vessel MI, target lesion revascularization) at 3 yearscomposite
Main Result
Hazard Ratio: 1.324 (95% CI 1.095–1.601)
Absolute Event Rate: 27.4% vs 15.2%
p-value: p=0.004
SYNTAX Score II is superior to the original SYNTAX Score for predicting patient-oriented composite outcomes at 3 years in patients with complex coronary artery disease treated with contemporary everolimus-eluting stents.
Limitations
- Registries only included patients undergoing PCI, precluding comparison with CABG.
- Study patients were implanted with only CoCr-EES among various contemporary DESs.
- Selection bias as patients unsuitable for CABG might have worse outcomes.
Cite This Study
Kang et al. (2019) conducted a cohort in Left main and/or 3-vessel coronary artery disease (n=1,248). SYNTAX Score and SYNTAX Score II vs. Low SYNTAX Score was evaluated on 3-year patient-oriented composite endpoint (POCE; all-cause death, any myocardial infarction, any revascularization) (HR 1.324, 95% CI 1.095-1.601, p=0.004). The SYNTAX Score II was superior to the anatomical SYNTAX Score for predicting 3-year patient-oriented composite endpoints (AUC 0.669 vs 0.611, p=0.019) in patients with left main and/or 3-vessel disease undergoing PCI.
View Full Paper
Ask AI
Bookmark
Share