Key result
Infarcted rat myocardium shows greater collagen fibril straightening at higher pressures versus normal tissue.
Population
Rat model of myocardial infarction induced by ligation of the left anterior descending artery for 2 weeks
Comparison
Passive loading/inflation at different… vs Normal myocardial tissue
Design
Preclinical
Follow-up
2 weeks
Authors
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Challenges assumption that collagen straightening drives infarct stiffness in rats; leaves open distinct 3D fiber architecture for mechanistic studies.
Absolute Event Rate: 1.056% vs 1.024%
The greater stiffness of infarcted tissue at low pressure is not due to straightened collagen fibers, suggesting a different three-dimensional structure of infarct versus normal coiled collagen fibers.
Jeffrey H. Omens (1997) studied Myocardial infarction. Infarcted myocardium vs. Normal tissue was evaluated on Collagen tortuosity at P = 20 mmHg. Infarcted rat myocardium showed greater collagen fibril straightening at higher pressures compared to normal tissue (1.056 vs. 1.024 at 20 mmHg), despite similar tortuosities at zero pressure.
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