Key result
Severe bilateral HCM and valvular endocardiosis cause fatal heart failure in a Gambian giant pouched rat.
Case Report (n=1)
This case report provides the first description of endocardiosis causing chronic heart failure in a Gambian giant pouched rat.
Endocardiosis may cause heart failure in Gambian giant pouched rats; first report extends cardiac pathology knowledge but remains hypothesis-generating.
A 1.5-yr-old captive male Gambian giant pouched rat (Cricetomys gambianus) died after suffering from anorexia, weakness, and dyspnea for 3 wk. Thoracic radiographs of thorax and abdomen and computed tomography showed a severe biventricular enlargement of the heart and a moderate hepatomegaly. Necropsy revealed a severe, bilateral hypertrophic cardiomyopathy and dilation of the right ventricle due to multifocal bilateral, valvular endocardiosis of all atrioventricular valves and acute hepatic congestion. Histologically, the atrioventricular valves were multifocally thickened by a marked endocardiosis with stromal accumulation of Periodic acid-Schiff (PAS)-positive, mucinous material. Although common in dogs, endocardiosis has not been described in Nesomyidaes. As in other affected species, the pathogenesis of endocardiosis in this species remains unclear.
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Müller et al. (2010) conducted a case report in Chronic Heart Failure due to Severe Endocardiosis (n=1). Severe Endocardiosis was evaluated on Necropsy findings. A 1.5-year-old captive male Gambian giant pouched rat died from chronic heart failure caused by severe, bilateral hypertrophic cardiomyopathy and multifocal valvular endocardiosis.
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