Key result
Ibuprofen pretreatment increases perioperative blood loss by ~365 mL versus placebo in elective hip surgery.
Why the study?
Does ibuprofen pretreatment increase perioperative blood loss in patients scheduled for total hip replacement?
Population
50 patients scheduled for total hip replacement
Comparison
Ibuprofen pretreatment for 2 weeks before… vs Placebo drug pretreatment for 2 weeks before…
Design
RCT, randomized manner, double blind
Follow-up
perioperative
Authors
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Avoid ibuprofen pretreatment before elective hip arthroplasty; confirms increased perioperative blood loss with preoperative NSAIDs in RCT evidence.
RCT (n=50)
Double-blind
randomized
Does ibuprofen pretreatment increase perioperative blood loss in patients scheduled for total hip replacement?
Absolute Event Rate: 1161% vs 796%
Pretreatment with ibuprofen before elective total hip surgery significantly increases perioperative blood loss, supporting the early discontinuation of non-selective NSAIDs prior to surgery.
Slappendel et al. (2002) conducted an RCT in Total hip replacement (n=50). Ibuprofen vs. Placebo was evaluated on Perioperative blood loss. Pretreatment with ibuprofen for 2 weeks before elective total hip surgery increased perioperative blood loss compared with placebo (1161 ± 472 mL vs 796 ± 337 mL).