Key result
Mechanical heart valves exhibit flow separations in scaled aortic models, increasing thrombus accumulation risk.
Population
3:1 scaled model of the human aorta
Design
Preclinical
Authors
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May inform mechanical valve design refinements; leaves open clinical translation to reduced thrombosis.
In vitro modeling of mechanical aortic valves demonstrates that flow separations at inner ring surfaces and occluders increase the risk of thrombus accumulation and turbulent shear stress.
Knoch et al. (1988) studied Mechanical aortic heart valve prostheses. Mechanical aortic heart valve prostheses was evaluated on Flow fields and pressure loss coefficients. In a 3:1 scaled model of the human aorta, mechanical heart valve prostheses exhibited flow separations at inner ring surfaces and occluders, increasing the risk of thrombus accumulation.
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