Key result
Chronic CHF linked to a ~33% relative increase in slow MHC I in the costal diaphragm.
Why the study?
Does chronic congestive heart failure alter the myofibrillar protein composition of the human diaphragm?
Observational
Does chronic congestive heart failure alter the myofibrillar protein composition of the human diaphragm?
Absolute Event Rate: 57% vs 43%
p-value: p=<0.001
Chronic congestive heart failure elicits a fast-to-slow transformation of myosin and regulatory proteins in the human costal diaphragm, increasing its slow-twitch characteristics.
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CHF may induce slow-twitch myosin shift in diaphragm; hypothesis-generating for respiratory outcomes and requires prospective confirmation.
Tikunov et al. (1996) conducted an observational in Chronic congestive heart failure. Chronic congestive heart failure vs. Control subjects was evaluated on Percentage of slow MHC I isoform in costal diaphragm (p=<0.001). Chronic congestive heart failure increased the percentage of slow MHC I (57% vs 43%) and decreased fast MHC IIb (8% vs 17%) in the human costal diaphragm (P<0.001).
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