Why the study?
Are there histological abnormalities in limb and respiratory muscles of patients with chronic heart failure compared to controls?
Population
34 subjects including 17 controls with normal left ventricular function and 17 patients with heart failure…
Comparison
Muscle biopsies of the quadriceps femoris… vs Control subjects with normal left ventricular…
Design
Case-control
Authors
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Suggests diaphragmatic histology may contribute to dyspnea in idiopathic dilated cardiomyopathy; hypothesis-generating and needs prospective validation.
Are there histological abnormalities in limb and respiratory muscles of patients with chronic heart failure compared to controls?
Histological abnormalities are present in the limb and respiratory muscles of patients with chronic heart failure, particularly those with idiopathic dilated cardiomyopathy, which may contribute to the pathogenesis of dyspnoea.
Lindsay et al. (1996) studied this question.
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