Key result
Specific BioFire FilmArray rhinovirus targets linked to ~28-fold higher odds of confirmed EV-D68 positivity.
Why the study?
Can the BioFire FilmArray respiratory panel identify patterns associated with enterovirus D68 to aid in confirmation triaging?
Observational (n=89)
Can the BioFire FilmArray respiratory panel identify patterns associated with enterovirus D68 to aid in confirmation triaging?
Odds Ratio: 27.75
The BioFire FilmArray respiratory panel may reveal target patterns useful for triaging suspected EV-D68 specimens for confirmation.
FA patterns may aid EV-D68 triaging; leaves open prospective validation before routine adoption.
During the enterovirus D68 (EV-D68) outbreak of 2014, the BioFire FilmArray (FA) respiratory panel was used to detect rhinovirus/enterovirus in respiratory specimens; suspected EV-D68-positive specimens were sent to CDC for confirmation. Positive rhinovirus/enterovirus FA targets revealed patterns loosely associated with EV-D68 that may be useful for confirmation triaging.
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Shibib et al. (2015) conducted an observational in Suspected enterovirus D68 (EV-D68) infection (n=89). BioFire FilmArray respiratory panel HRV target patterns (HRV 1 and 4, or HRV 1, 2, and 4) vs. Other HRV target patterns was evaluated on Association with confirmed EV-D68 positivity (OR 27.75). The presence of human rhinovirus targets 1 and 4, or 1, 2, and 4 on the BioFire FilmArray respiratory panel was 27.8 times more likely to be associated with a confirmed EV-D68-positive specimen.
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