Key result
Oral mexiletine fails to alter LV contractility in patients with congestive heart failure.
Why the study?
Does oral mexiletine administration affect left ventricular contractility in patients with congestive heart failure and ventricular arrhythmias?
Population
8 patients with congestive heart failure accompanied by significant functional mitral regurgitation who had…
Comparison
Mexiletine 300 mg oral daily for 2 to 4 weeks. vs Baseline (before mexiletine administration).
Design
Case_series
Follow-up
2 to 4 weeks
Authors
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Supports mexiletine safety on LV contractility in HF; leaves open confirmation in controlled trials.
Does oral mexiletine administration affect left ventricular contractility in patients with congestive heart failure and ventricular arrhythmias?
Absolute Event Rate: 650% vs 640%
Oral mexiletine administration for 2 to 4 weeks does not significantly alter left ventricular contractility in patients with congestive heart failure.
Morita et al. (1995) studied Congestive heart failure with mitral regurgitation (n=8). Mexiletine vs. Baseline (before administration) was evaluated on Left ventricular contractility (ICT delta P/delta t). Oral administration of mexiletine 300 mg daily for 2 to 4 weeks did not change left ventricular contractility (650 vs 640 mm Hg/sec) in patients with congestive heart failure.
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