What is the clinical evidence from this study?

Study design: Other. Population: Digoxin pharmacokinetics (n=43). Intervention: Modified EMIT 2000 digoxin assay vs. Original EMIT 2000 digoxin assay. Primary outcome: Digoxin plasma concentrations.

What does this research mean for the field?

A modified EMIT 2000 digoxin assay achieves a lower limit of quantification of 0.08 ng/mL, comparable to radioimmunoassay, without differing significantly from the original assay in patient samples. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

April 1, 1999Therapeutic Drug Monitoring

Improved Sensitivity of Digoxin Assay by Modification of the EMIT 2000 Method

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Key result

Modified EMIT 2000 digoxin assay matches the original assay and achieves RIA-level quantification limits.

n=43

Population

25 plasma specimens from patients receiving digoxin and 18 healthy volunteers

Comparison

Modified EMIT 2000 digoxin assay vs Original EMIT 2000 digoxin assay and literature…

Design

Other

Authors

NRNathalie RadembinoHôpital Saint-Antoine JPJean‐Marie PoirierCentre National de la Recherche Scientifique IRIsabelle RagueneauUniversity of Washington

Discussion

Member takes

Implication

Supports modified digoxin assay for pharmacokinetic studies; leaves open routine clinical adoption pending further validation.

Structured PICO

Population

25 plasma specimens from patients receiving digoxin and 18 healthy volunteers administered a single 0.5 mg oral dose to evaluate a modified EMIT 2000 digoxin assay.

Exposure

Modified EMIT 2000 digoxin assay (higher plasma volume, calibration curves 0-2 ng/ml with biological matrix)

Comparator

Original EMIT 2000 digoxin assay (for patient specimens) and literature RIA values (for PK study)

Outcome

Assay performance (detection/quantification limits, precision) and digoxin pharmacokinetic parameterssurrogate

The modified EMIT 2000 digoxin assay provides sensitivity comparable to radioimmunoassay, making it suitable for pharmacokinetic interaction studies.

Cite This Study

Radembino et al. (1999) studied Digoxin pharmacokinetics (n=43). Modified EMIT 2000 digoxin assay vs. Original EMIT 2000 digoxin assay was evaluated on Digoxin plasma concentrations. The modified EMIT 2000 digoxin assay demonstrated a lower limit of quantification of 0.08 ng/mL, similar to radioimmunoassay, and showed no significant difference compared to the original assay.

synapsesocial.com/papers/6aa6f3f4bb64cafef81b3238 https://doi.org/10.1097/00007691-199904000-00019

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Improved Sensitivity of Digoxin Assay by Modification of the EMIT 2000 Method

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Improved Sensitivity of Digoxin Assay by Modification of the EMIT 2000 Method

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider