Key result
The functional bioprosthetic heart valve material OX-CA-PP exhibited superior anti-inflammation, improved anti-coagulation, minimal calcification, and promoted endothelial cell proliferation.
A novel chlorogenic acid-based non-glutaraldehyde functional strategy for bioprosthetic heart valves demonstrates favorable anti-inflammatory, anti-coagulant, and anti-calcification properties in experimental models.
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May advance non-glutaraldehyde bioprosthetic valves; leaves open clinical translation pending human trials.
experimental results show that the functional BHV material OX-CA-PP exhibits superior anti-inflammation, improved anti-coagulation, minimal calcification and promoted proliferation of endothelial cells, showing that this non-glutaraldehyde functional strategy has great potential for the application of BHVs and providing a promising reference for other implanted biomaterials.
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Chen et al. (2023) studied this question. The functional bioprosthetic heart valve material OX-CA-PP exhibited superior anti-inflammation, improved anti-coagulation, minimal calcification, and promoted endothelial cell proliferation.
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