Effect of coronary artery bypass graft surgery on left ventricular systolic function
Key result
CABG is linked to improved LVEF in ~24% of patients, primarily those with lower baseline LVEF.
- n=375
Why the study?
Does isolated CABG improve left ventricular systolic function in patients with coronary artery disease?
Population
n=375 patients who underwent isolated CABG and had echocardiographic assessment of LV function before and…
Comparison
Isolated coronary artery bypass grafting (CABG) vs Pre-operative baseline
Design
Cohort
Follow-up
3 to 24 months
Authors
Discussion
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Implication
May support selective CABG in low LVEF but caution in normal; leaves open randomized trials on net LV outcomes in CAD.
Study Design
Type
Cohort (n=375)
Multicenter
No
Structured PICO
Does isolated CABG improve left ventricular systolic function in patients with coronary artery disease?
P
Population
375 patients who underwent isolated CABG and had echocardiographic assessments before and 3 to 24 months after surgery.
E
Exposure
Isolated coronary artery bypass grafting (CABG)
C
Comparator
Pre-operative baseline (within 6 months before CABG)
O
Outcome
Changes in left ventricular (LV) systolic function (LVEF) assessed by echocardiographysurrogate
CABG is associated with improved LV systolic function in patients with decreased pre-operative LVEF, but may decrease LV function in those with normal pre-operative LVEF.
Cite This Study
Koene et al. (2017) conducted a cohort in Coronary artery disease requiring isolated CABG (n=375). Coronary artery bypass grafting (CABG) vs. Pre-operative baseline was evaluated on Changes in left ventricular (LV) systolic function. Coronary artery bypass grafting was associated with improved LVEF (>5%) in 24% of patients, no change in 55%, and worsened LVEF in 21%, with improvements seen in those with lower baseline LVEF.