Unraveling a case of pantoprazole-induced-anaphylaxis requiring tracheostomy: A case report

Background: Proton pump inhibitors (PPIs) are used by 50.85%, 42.16%, and 40.97% of doctors, nurses, and pharmacists, respectively.The reported incidence of anaphylaxis with PPIs is under 1%. Case Presentation:We present the first-ever reported case of anaphylaxis to pantoprazole, which failed medical management with multiple attempts for endotracheal and nasotracheal intubation failed due to diffuse edema, necessitating the need for an urgent tracheostomy and mechanical ventilation.Famotidine replaced pantoprazole throughout the hospital course, and he had no further hypersensitivity reactions.Conclusion: PPIs are effective but not without severe complications.Unfortunately, anaphylaxis is often misdiagnosed, increasing the risk of mortality and morbidity.Although anaphylaxis is rare, these reactions can be life-threatening.Emergency medicine and primary care physicians must be aware of the potential side effects of PPIs and should carefully monitor patients in inpatient and outpatient clinical settings.