Genetic causes of human heart failure
Key result
Single-gene defect analyses clarify cardiac remodeling and highlight novel therapeutic targets for heart failure.
Population
Patients with cardiovascular disease at high risk for heart failure
Design
Review
Authors
Discussion
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Member takes
Implication
Does not yet change HF practice; leaves open translation of monogenic insights to acquired disease therapies.
Structured PICO
P
Population
Patients with cardiovascular disease at high risk for heart failure
Understanding single-gene defects in myocardial diseases provides critical insights into the mechanisms of cardiac remodeling and may help identify novel therapeutic targets for heart failure.
Cite This Study
Morita et al. (2005) conducted a review in Heart failure. Single-gene defects was evaluated. Analyses of single-gene defects provide insights into cardiac remodeling and heart failure, showing promise for defining novel therapeutic targets for genetic and acquired causes of the disease.