Key result
ACE DD links to slower post-exercise SBP recovery and ACTN3 RR to lower maximal SBP.
Why the study?
Do ACE and ACTN3 gene polymorphisms affect blood pressure response to acute exercise in elite male athletes?
Population
107 elite male Serbian athletes classified by sporting discipline (power/sprint, endurance, or mixed sports)
Comparison
Presence of ACE and ACTN3 gene polymorphisms vs Absence of these specific genetic polymorphisms…
Design
Cross-sectional
Authors
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ACE/ACTN3 variants associate with exercise BP recovery in athletes; hypothesis-generating for personalized monitoring, prospective validation required.
Cross-Sectional (n=107)
No
Do ACE and ACTN3 gene polymorphisms affect blood pressure response to acute exercise in elite male athletes?
Absolute Event Rate: 80.4% vs 78.3%
p-value: p=0.006
ACE and ACTN3 gene polymorphisms influence blood pressure responses to acute exercise in elite athletes, though long-term blood pressure adaptations appear driven by the specific sporting discipline rather than these genetic variants.
Durmić et al. (2017) conducted a cross-sectional in Healthy elite athletes (n=107). ACE I/D and ACTN3 R577X polymorphisms vs. Alternative genotypes (e.g., ACE ID/II, ACTN3 RR) was evaluated on Third minute post-exercise systolic blood pressure ratio (SBPR3) (p=0.006). The ACE DD genotype was associated with a significantly slower systolic blood pressure recovery after acute exercise, while the ACTN3 RR genotype was associated with lower maximal systolic blood pressure in elite male athletes.
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