Key result
Graded hypoxia increases ATP utilization in mature versus newborn lambs despite similar mitochondrial function during reoxygenation.
Population
Newborn (4-10 days old, n=6) and mature sheep (30-60 days old, n=6)
Comparison
Graded hypoxia and reoxygenation vs Comparison between newborn and mature sheep
Design
Preclinical
Authors
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Developmental differences in hypoxic ATP use warrant larger animal models; leaves open translation to human neonatal cardioprotection.
Absolute Event Rate: 34% vs 26%
Despite greater energy imbalance during hypoxia in mature lambs compared to newborns, mitochondrial function during reoxygenation remains similar across developmental stages.
Portman et al. (1996) studied Hypoxia (n=12). Graded hypoxia and reoxygenation vs. Mature sheep (compared to newborn sheep) was evaluated on Creatine rephosphorylation rates (percentage of predicted values). Graded hypoxia resulted in greater ATP utilization in mature lambs compared to newborns, though mitochondrial function during reoxygenation was similar (34% vs 26% predicted creatine rephosphorylation).
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