What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Basal ganglia enlarged perivascular spaces (BG-EPVS) (n=485). Intervention: Carotid-femoral pulse wave velocity (cf-PWV) ≥ 10 m/s vs. cf-PWV < 10 m/s. Primary outcome: Basal ganglia enlarged perivascular spaces (BG-EPVS) (OR 2.06, 95% CI 1.27-3.36).

What does this research mean for the field?

Higher carotid-femoral pulse wave velocity is independently and dose-dependently associated with basal ganglia enlarged perivascular spaces, with systolic blood pressure and pulse pressure mediating approximately 43% of this association. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To assess the relationship between carotid-femoral pulse wave velocity and basal ganglia enlarged perivascular spaces, while determining the mediating role of blood pressure components in community-based adults.

September 14, 2026Journal of Clinical HypertensionOpen Access

Blood Pressure Mediates the Association Between Carotid‐Femoral Pulse Wave Velocity and Basal Ganglia Enlarged Perivascular Spaces: A Community‐Based Cross‐Sectional Study

Q: What are the key findings of this study?

Carotid-femoral pulse wave velocity ≥ 10 m/s was independently associated with basal ganglia enlarged perivascular spaces (OR 2.06; 95% CI 1.27-3.36), with systolic BP and pulse pressure mediating ~43% of the effect.

Q: What does this research mean for the field?

Higher carotid-femoral pulse wave velocity is independently and dose-dependently associated with basal ganglia enlarged perivascular spaces, with systolic blood pressure and pulse pressure mediating approximately 43% of this association. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Q: What question did this study set out to answer?

To assess the relationship between carotid-femoral pulse wave velocity and basal ganglia enlarged perivascular spaces, while determining the mediating role of blood pressure components in community-based adults.

View Full Paper

Ask AI

Bookmark

Why the study?

Is higher carotid-femoral pulse wave velocity associated with basal ganglia enlarged perivascular spaces, and does blood pressure mediate this association?

Population

485 community-based adults from the Kailuan cohort

Comparison

Higher carotid-femoral pulse wave velocity vs Lower carotid-femoral pulse wave velocity

Design

Cross-sectional

Key result

Carotid-femoral pulse wave velocity ≥ 10 m/s was independently associated with basal ganglia enlarged perivascular spaces (OR 2.06; 95% CI 1.27-3.36), with systolic BP and pulse pressure mediating ~43% of the effect.

Authors

SLShang Li YLYuan Liu PYPeipei Yang

Discussion

Member takes

Overview

Supports cf-PWV as potential BG-EPVS marker in community adults; leaves open causality and clinical utility pending longitudinal data.

Key Points

To assess the relationship between carotid-femoral pulse wave velocity and basal ganglia enlarged perivascular spaces, while determining the mediating role of blood pressure components in community-based adults.
Analyzed cross-sectional data from 485 community-dwelling participants within the Kailuan cohort.
Measured carotid-femoral pulse wave velocity (cf-PWV) using ultrasound and evaluated basal ganglia enlarged perivascular spaces (BG-EPVS) via 3.0-Tesla MRI.
Applied multivariable logistic regression, restricted cubic spline analyses, and mediation models to quantify direct and indirect effects of systolic, diastolic, and pulse pressure.
BG-EPVS was identified in 59.4% of participants.
Aortic stiffness (cf-PWV ≥ 10 m/s) was independently associated with BG-EPVS (OR = 2.06, 95% CI: 1.27–3.36) with a linear dose-response relationship (p for non-linearity = 0.668), showing stronger effects in males and individuals aged ≤ 70 years.
Systolic blood pressure and pulse pressure mediated 43.0% and 43.6% of the total effect of cf-PWV on BG-EPVS, respectively, whereas diastolic blood pressure showed no significant mediation.

Study Design

Type

Cross-Sectional (n=485)

Structured PICO

Is higher carotid-femoral pulse wave velocity associated with basal ganglia enlarged perivascular spaces, and does blood pressure mediate this association?

Population

485 community-based adults from the Kailuan cohort assessed for the association between carotid-femoral pulse wave velocity and basal ganglia enlarged perivascular spaces.

Exposure

Higher carotid-femoral pulse wave velocity (cf-PWV ≥ 10 m/s)

Comparator

Lower carotid-femoral pulse wave velocity

Outcome

Basal ganglia enlarged perivascular spaces (BG-EPVS) graded on 3.0-Tesla MRIsurrogate

Main Result

Odds Ratio: 2.06 (95% CI 1.27–3.36)

Aortic stiffness is independently associated with basal ganglia enlarged perivascular spaces, an effect substantially mediated by pulsatile blood pressure components.

Cite This Study

Li et al. (2026) conducted a cross-sectional in Basal ganglia enlarged perivascular spaces (BG-EPVS) (n=485). Carotid-femoral pulse wave velocity (cf-PWV) ≥ 10 m/s vs. cf-PWV < 10 m/s was evaluated on Basal ganglia enlarged perivascular spaces (BG-EPVS) (OR 2.06, 95% CI 1.27-3.36). Carotid-femoral pulse wave velocity ≥ 10 m/s was independently associated with basal ganglia enlarged perivascular spaces (OR 2.06; 95% CI 1.27-3.36), with systolic BP and pulse pressure mediating ~43% of the effect.

synapsesocial.com/papers/6aa7afef79e9260bc85aacb0 https://doi.org/10.1111/jch.70363

View Full Paper

Ask AI

Bookmark

September 14, 2026Journal of Clinical HypertensionOpen Access

Blood Pressure Mediates the Association Between Carotid‐Femoral Pulse Wave Velocity and Basal Ganglia Enlarged Perivascular Spaces: A Community‐Based Cross‐Sectional Study

View Full Paper

Ask AI

Bookmark

Why the study?

Is higher carotid-femoral pulse wave velocity associated with basal ganglia enlarged perivascular spaces, and does blood pressure mediate this association?

Population

485 community-based adults from the Kailuan cohort

Comparison

Higher carotid-femoral pulse wave velocity vs Lower carotid-femoral pulse wave velocity

Design

Cross-sectional

Key result

Authors

SLShang Li YLYuan Liu PYPeipei Yang

Discussion

Member takes

Overview

Supports cf-PWV as potential BG-EPVS marker in community adults; leaves open causality and clinical utility pending longitudinal data.

Key Points

To assess the relationship between carotid-femoral pulse wave velocity and basal ganglia enlarged perivascular spaces, while determining the mediating role of blood pressure components in community-based adults.
Analyzed cross-sectional data from 485 community-dwelling participants within the Kailuan cohort.
Measured carotid-femoral pulse wave velocity (cf-PWV) using ultrasound and evaluated basal ganglia enlarged perivascular spaces (BG-EPVS) via 3.0-Tesla MRI.
Applied multivariable logistic regression, restricted cubic spline analyses, and mediation models to quantify direct and indirect effects of systolic, diastolic, and pulse pressure.
BG-EPVS was identified in 59.4% of participants.
Aortic stiffness (cf-PWV ≥ 10 m/s) was independently associated with BG-EPVS (OR = 2.06, 95% CI: 1.27–3.36) with a linear dose-response relationship (p for non-linearity = 0.668), showing stronger effects in males and individuals aged ≤ 70 years.
Systolic blood pressure and pulse pressure mediated 43.0% and 43.6% of the total effect of cf-PWV on BG-EPVS, respectively, whereas diastolic blood pressure showed no significant mediation.

Study Design

Type

Cross-Sectional (n=485)

Structured PICO

Is higher carotid-femoral pulse wave velocity associated with basal ganglia enlarged perivascular spaces, and does blood pressure mediate this association?

Population

485 community-based adults from the Kailuan cohort assessed for the association between carotid-femoral pulse wave velocity and basal ganglia enlarged perivascular spaces.

Exposure

Higher carotid-femoral pulse wave velocity (cf-PWV ≥ 10 m/s)

Comparator

Lower carotid-femoral pulse wave velocity

Outcome

Basal ganglia enlarged perivascular spaces (BG-EPVS) graded on 3.0-Tesla MRIsurrogate

Main Result

Odds Ratio: 2.06 (95% CI 1.27–3.36)

Aortic stiffness is independently associated with basal ganglia enlarged perivascular spaces, an effect substantially mediated by pulsatile blood pressure components.

Cite This Study

synapsesocial.com/papers/6aa7afef79e9260bc85aacb0 https://doi.org/10.1111/jch.70363

View Full Paper

Ask AI

Bookmark