Key result
Insulin infusion reduces severe hypertriglyceridemia by ~72% in a non-diabetic pregnant woman, enabling safe delivery.
Why the study?
Severe hypertriglyceridaemia in pregnancy can cause acute pancreatitis with high maternal and perinatal mortality, but safe treatment options to rapidly reduce triglycerides are limited.
Does insulin safely reduce triglyceride levels in pregnant women without diabetes presenting with severe hypertriglyceridaemia?
Case Report (n=1)
No
Does insulin safely reduce triglyceride levels in pregnant women without diabetes presenting with severe hypertriglyceridaemia?
Insulin may be a safe and effective treatment for severe hypertriglyceridaemia in pregnant women without diabetes.
May support insulin for severe hypertriglyceridaemia in pregnancy; hypothesis-generating and requires prospective trials before practice change.
Severe hypertriglyceridaemia can lead to acute pancreatitis, which is associated with maternal and perinatal mortality when it occurs in pregnancy. Rapid reduction of triglyceride levels is a primary goal in the management of severe hypertriglyceridaemia, however, there are limited safe option for treatment in pregnancy. We present a case of a woman without diabetes presenting with severe hypertriglyceridaemia in late gestation who was safely and successfully treated with insulin and review the literature surrounding the management of this important condition.
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Aleena S. Ali (2021) conducted a case report in Severe hypertriglyceridaemia in pregnancy (n=1). Insulin infusion was evaluated on Triglyceride level. An insulin infusion successfully reduced severe hypertriglyceridaemia from 107.5 mmol/L to 30.4 mmol/L over 4 days in a pregnant woman without diabetes, allowing for safe delivery.
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